PT-141 (Bremelanotide) Nasal Spray

Direct Anti Peptide is proud to offer PT-141 (Bremelanotide) Nasal Spray, a premium-grade research peptide formulated at ≥98% purity and supplied in a convenient nasal spray delivery format. Designed exclusively for qualified researchers and laboratory professionals, this product represents a sophisticated tool for advancing the scientific understanding of melanocortin receptor biology. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

PT-141, also known by its INN designation Bremelanotide, is a synthetic cyclic heptapeptide that functions as a non-selective agonist of melanocortin receptors, particularly MC1R, MC3R, MC4R, and MC5R. Originally derived from Melanotan II, PT-141 was developed to explore central nervous system pathways involved in arousal-related signalling. The nasal spray format provides researchers with a practical, non-invasive delivery mechanism that facilitates rapid absorption across the nasal mucosa, bypassing first-pass hepatic metabolism and offering a reliable model for transmucosal peptide uptake studies.

Peptide Structure & Amino Acid Sequence

PT-141 (Bremelanotide) is a cyclic lactam heptapeptide with the amino acid sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. Its cyclic structure confers enhanced metabolic stability compared to linear analogues, making it particularly useful in studies examining peptide resistance to enzymatic degradation. The inclusion of a D-phenylalanine residue at position 4 and the cyclic lactam bridge between aspartic acid and lysine residues are defining structural features that contribute to its receptor selectivity profile and research utility.

Chemical & Physical Characteristics

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.17 g/mol
• CAS Number: 189691-06-3
• Appearance: White to off-white lyophilised powder (prior to formulation)
• Solubility: Soluble in aqueous buffer systems; formulated for nasal mucosal delivery
• Storage Conditions: Store at 2–8°C; protect from light and moisture
• Delivery Format: Nasal spray solution

Purity & Analytical Verification (HPLC & MS)

Every batch of PT-141 (Bremelanotide) Nasal Spray supplied by Direct Anti Peptide is independently verified to a minimum purity of ≥98% using high-performance liquid chromatography (HPLC). Mass spectrometry (MS) analysis is conducted to confirm molecular identity and the absence of synthesis-related impurities. These rigorous analytical protocols ensure that researchers receive a consistent, reliable product that meets the demanding standards required for reproducible laboratory investigations.

Quality Control & Lyophilisation Integrity

Prior to spray formulation, the active peptide compound undergoes lyophilisation under controlled conditions to preserve structural integrity and biological activity across the supply chain. Each production lot is subject to strict quality control checkpoints, including sterility screening of the formulation environment, osmolality verification of the final spray solution, and stability assessments under accelerated conditions. Our quality management processes are designed to deliver a product that performs consistently across research applications.

Safety, Handling & Laboratory Precautions

PT-141 (Bremelanotide) Nasal Spray is a research-grade compound intended solely for use by trained laboratory professionals in controlled research environments. Personnel handling this compound should wear appropriate personal protective equipment (PPE), including nitrile gloves, eye protection, and a laboratory coat. Avoid inhalation of any aerosol generated during handling. All waste materials must be disposed of in accordance with applicable local, national, and institutional regulations governing research chemicals. This product must not be used on or administered to humans or animals under any circumstances.

Reconstitution, Packaging & Storage

PT-141 (Bremelanotide) Nasal Spray is supplied ready-formulated in a pharmaceutical-grade nasal spray delivery device, enabling precise and consistent volume delivery per actuation for research dosimetry studies. Each unit is sealed to prevent contamination and degradation during transit. Upon receipt, store immediately at 2–8°C in a refrigerated environment away from direct light. Do not freeze the formulated spray solution. Refer to the certificate of analysis (CoA) included with each shipment for batch-specific storage and stability data.

Intended Research Use & Market Positioning

PT-141 (Bremelanotide) Nasal Spray is positioned as a leading research tool for scientists investigating melanocortin receptor pharmacology, central nervous system signalling cascades, and transmucosal peptide delivery mechanisms. The nasal spray format is of particular interest to researchers studying absorption kinetics, bioavailability modelling, and formulation science. Direct Anti Peptide supplies this compound to academic institutions, contract research organisations (CROs), and independent research laboratories seeking high-purity peptide reagents at competitive prices.

Ordering, Availability & Fulfillment

Direct Anti Peptide makes it straightforward to buy PT-141 (Bremelanotide) Nasal Spray online with confidence. Our secure eCommerce platform offers transparent pricing, fast order processing, and reliable international dispatch. All orders are fulfilled with a batch-specific certificate of analysis and appropriate research-use documentation. Whether you are looking to order a single unit or place a bulk research order, our team is available to support your procurement needs. Browse our full peptide catalogue and order now to take advantage of our best price guarantee on premium research peptides.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. PT-141 (Bremelanotide) Nasal Spray is sold exclusively as a laboratory research reagent. Direct Anti Peptide does not endorse, promote, or facilitate the use of this compound outside of strictly controlled scientific research settings. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the acquisition, storage, handling, and use of research peptides. This product is not a medicinal product and has not been approved by any regulatory authority for therapeutic use.