SS-31 Nasal Spray

Direct Anti Peptide supplies SS-31 Nasal Spray as a high-purity, laboratory-grade research peptide intended exclusively for qualified research professionals working within controlled scientific environments. Produced at ≥98% purity and rigorously quality-tested, this compound represents a compelling tool for researchers studying mitochondrial biology, oxidative stress pathways, and related cellular mechanisms.

Product Overview

SS-31 (also known as Elamipretide or MTP-131) is a tetrapeptide belonging to the Szeto-Schiller family of mitochondria-targeting peptides. Its unique design allows it to selectively concentrate within the inner mitochondrial membrane, where it interacts with cardiolipin — a phospholipid critical to mitochondrial structural integrity and function. Research into SS-31 spans cardiovascular biology, neurodegenerative disease models, renal function studies, and cellular aging, making it one of the most scientifically discussed mitochondria-targeted compounds available for laboratory research today.

Peptide Structure & Amino Acid Sequence

SS-31 is a water-soluble, aromatic-cationic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂, where Dmt denotes 2′,6′-dimethyltyrosine. This alternating aromatic-cationic motif is central to its mitochondrial targeting behaviour and its ability to associate with cardiolipin on the inner mitochondrial membrane. The peptide’s compact four-residue structure, combined with its amphipathic character, facilitates membrane penetration without dependence on mitochondrial membrane potential, distinguishing it from earlier-generation mitochondria-targeting agents.

Chemical & Physical Characteristics

• Peptide Sequence: D-Arg-Dmt-Lys-Phe-NH₂
• Molecular Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: Approximately 639.8 g/mol
• Appearance: Clear to slightly opalescent aqueous nasal spray solution
• Solubility: Water-soluble
• Purity: ≥98% (HPLC verified)
• Format: Nasal spray formulation, research-grade

Purity & Analytical Verification (HPLC & MS)

Every batch of SS-31 Nasal Spray offered by Direct Anti Peptide undergoes stringent analytical verification prior to release. High-Performance Liquid Chromatography (HPLC) is employed to confirm peptide purity at ≥98%, ensuring minimal presence of truncated sequences, deletion products, or synthesis-related impurities. Mass Spectrometry (MS) is used to verify the correct molecular mass and confirm peptide identity. These dual analytical methods provide researchers with the confidence required for reproducible, high-integrity experimental outcomes.

Quality Control & Lyophilization Integrity

The nasal spray formulation undergoes controlled manufacturing processes designed to preserve peptide integrity throughout preparation and storage. Sterile filtration and validated filling procedures are applied to maintain solution clarity and consistent concentration. Batch-specific Certificates of Analysis (CoA) are available upon request, providing full traceability of purity data and analytical results for each production lot supplied through Direct Anti Peptide.

Safety, Handling & Laboratory Precautions

SS-31 Nasal Spray is supplied exclusively for in vitro laboratory research use by trained and qualified research professionals. Standard laboratory personal protective equipment (PPE) — including gloves, eye protection, and appropriate laboratory attire — should be worn when handling this compound. Researchers should consult applicable institutional safety guidelines and relevant safety data documentation. This product is not approved for use in humans or animals and must not be administered, ingested, or applied in any clinical, therapeutic, or diagnostic context.

Reconstitution, Packaging & Storage

SS-31 Nasal Spray is supplied as a ready-to-use aqueous solution in a laboratory-grade nasal spray delivery format. No reconstitution is required. Upon receipt, the product should be stored in accordance with the conditions specified on the product label and accompanying documentation. Researchers are advised to avoid repeated freeze-thaw cycles and to maintain the product away from direct light and heat sources to preserve solution stability and peptide integrity throughout the research period.

Intended Research Use & Market Positioning

SS-31 Nasal Spray is positioned as a premium research tool for scientists investigating mitochondrial dysfunction, reactive oxygen species (ROS) biology, cardiolipin-peptide interactions, ATP synthesis modulation, and cellular bioenergetics. Research contexts of interest include in vitro models of cardiovascular disease, neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease, chronic kidney disease, and mitochondria-associated aging processes. Direct Anti Peptide offers this compound to support rigorous, reproducible scientific inquiry at the laboratory level.

Ordering, Availability & Fulfillment

Researchers can buy SS-31 Nasal Spray online directly through Direct Anti Peptide. We offer competitive best-price positioning on all research peptides, with streamlined order processing and reliable international fulfillment for qualified research institutions and laboratories. Orders are dispatched promptly following verification, with secure packaging designed to maintain product integrity during transit. Please note: this product is not available for purchase in the USA. Contact our team for regional availability and shipping inquiries before placing your order.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. SS-31 Nasal Spray is sold exclusively as a laboratory research reagent. It has not been evaluated or approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. All purchasers are solely responsible for ensuring compliance with applicable national, regional, and institutional regulations governing the procurement, handling, and use of research peptides. Direct Anti Peptide accepts no liability for misuse, unauthorised application, or non-compliant handling of this product outside of its intended research context.