PAL-GHK (Topical)

Product Overview

PAL-GHK, commonly referred to as Palmitoyl Tripeptide-1 or Palmitoyl Oligopeptide, is a synthetically produced topical research peptide available exclusively through Direct Anti Peptide for qualified laboratory and research procurement. Formed by conjugating a palmitoyl fatty acid chain to the tripeptide sequence Glycine-Histidine-Lysine (GHK), this compound has attracted consistent scientific interest due to its structural resemblance to type I collagen fragments and its demonstrated behavior in experimental skin tissue models. Researchers investigating extracellular matrix dynamics, fibroblast activity, and topical delivery systems frequently include PAL-GHK in their experimental panels. Direct Anti Peptide supplies this compound at ≥98% purity, making it a reliable choice for reproducible, high-integrity research outcomes.

Peptide Structure & Amino Acid Sequence

PAL-GHK is constructed from the tripeptide sequence Gly-His-Lys (GHK) with a palmitoyl (C16) fatty acid moiety covalently attached to the N-terminus. This lipid conjugation is the defining structural feature of the molecule, as it significantly alters the compound’s amphiphilic character relative to the unmodified GHK sequence. The palmitoyl chain enhances membrane affinity and facilitates passage through lipid-rich biological barriers encountered in topical research models. The resulting molecule closely mimics fragments derived from type I collagen degradation, a property that underpins much of the scientific interest in its interaction with dermal fibroblasts and connective tissue components in laboratory settings.

Chemical & Physical Characteristics

• Common Name: PAL-GHK / Palmitoyl Tripeptide-1 / Palmitoyl Oligopeptide
• Peptide Sequence: Palmitoyl-Gly-His-Lys
• Molecular Formula: C₃₀H₅₄N₆O₅
• Molecular Weight: Approximately 578.79 g/mol
• Appearance: White to off-white lyophilized powder
• Solubility: High aqueous solubility; compatible with lipid-based and liposomal carrier systems
• Application Format: Topical research formulation studies
• Purity: ≥98% (HPLC verified)

Purity & Analytical Verification (HPLC & MS)

Every batch of PAL-GHK supplied by Direct Anti Peptide undergoes rigorous analytical testing prior to release. High-Performance Liquid Chromatography (HPLC) is used to confirm peptide purity at ≥98%, while Mass Spectrometry (MS) validates the molecular identity and confirms correct palmitoyl conjugation and amino acid composition. These dual verification methods ensure that researchers receive a compound of consistent, documented quality — a critical requirement for reproducible experimental outcomes. Certificate of Analysis (CoA) documentation is available upon request and reflects batch-specific analytical data.

Quality Control & Lyophilization Integrity

PAL-GHK is produced under controlled synthesis conditions and subjected to multi-stage quality control protocols. Following synthesis and purification, the peptide is lyophilized (freeze-dried) to remove residual solvent and moisture, producing a stable powder with extended shelf life when stored under recommended conditions. Lyophilization also preserves structural integrity during transit and long-term storage, reducing the risk of degradation that can compromise experimental data. Direct Anti Peptide’s quality assurance process encompasses both in-process and final-product testing to uphold the highest standards expected by research institutions.

Safety, Handling & Laboratory Precautions

PAL-GHK is supplied exclusively for use by trained laboratory professionals in authorized research environments. Standard laboratory safety protocols must be observed at all times when handling this compound. Appropriate personal protective equipment (PPE), including gloves, eye protection, and lab coat, should be worn. The compound must be handled in a designated research setting with proper ventilation. This product is not evaluated for safety in biological systems and must not be used outside of a controlled laboratory context. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Reconstitution, Packaging & Storage

PAL-GHK is supplied as a lyophilized powder packaged under inert conditions to maintain stability. For laboratory reconstitution in experimental formulation studies, researchers typically explore aqueous buffers, liposomal carriers, or lipid-based delivery vehicles given the compound’s high aqueous solubility and demonstrated compatibility with lipid systems. All reconstitution decisions remain the sole responsibility of the qualified researcher and must be conducted in accordance with institutional protocols. Upon receipt, the lyophilized product should be stored at -20°C in a dry, dark environment. Reconstituted solutions, where applicable to the research design, should be aliquoted and stored at -80°C to minimize freeze-thaw degradation cycles.

Intended Research Use & Market Positioning

PAL-GHK occupies a well-established position within the topical peptide research segment. Its primary areas of scientific investigation include extracellular matrix (ECM) remodeling, fibroblast stimulation, collagen synthesis pathways, and topical penetration enhancement studies. Researchers working in dermatological science, biomaterial formulation, and cosmetic ingredient evaluation frequently procure this compound for inclusion in controlled in vitro and ex vivo experimental designs. The compound’s compatibility with liposomal delivery systems also makes it a candidate for targeted delivery mechanism studies. Direct Anti Peptide positions PAL-GHK as a premium-grade, analytically verified research tool for the serious scientific community.

Ordering, Availability & Fulfillment

Direct Anti Peptide offers PAL-GHK (Palmitoyl Tripeptide-1) for sale online with streamlined ordering, competitive best-price positioning, and efficient fulfillment logistics. Researchers and procurement officers can order now through our secure eCommerce platform, with options for institutional invoicing and bulk inquiry. All orders are processed promptly, with careful packaging designed to maintain lyophilized integrity throughout transit. Our customer support team is available to assist with CoA requests, product specifications, and order tracking. Buy online today and experience the Direct Anti Peptide standard of research-grade quality and service.

Legal & Regulatory Disclaimer

PAL-GHK (Palmitoyl Tripeptide-1) is sold by Direct Anti Peptide strictly as a laboratory research reagent. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. This product has not been evaluated or approved by any regulatory authority for use in humans or animals. It must not be administered to any living organism, used in food or beverage applications, or repurposed outside of an authorized laboratory research context. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the procurement, storage, and use of research peptides. Direct Anti Peptide assumes no liability for misuse or unauthorized application of this compound.